The PETA International Science Consortium and its members’ current and future research activities address a wide range of issues related to the replacement of animals in experimental procedures. The following are links to select scientific publications, posters, and presentations authored by the Science Consortium and its members. Additional resources for reducing animal use can be found here.
- Groff K, Brown J, Clippinger AJ. Affinity reagents to replace animal-derived antibodies [poster]. Baltimore, Maryland: Pan American Conference for Alternative Methods; 2016.
- Groff K, Brown J, Clippinger AJ. Modern affinity reagents: recombinant antibodies and aptamers. Biotechnol Adv. 2015;33(8):1787-1798.
- Echko M and Dozier SK. Recombinant antibody technology for the production of antibodies without the use of animals. Alttox.org. 2010.
- Dozier SK. Monoclonal antibodies: scientific uses and advantages of rAbs and aptamers. 2010.
- Manuppello J. Long-term carcinogenesis bioassays in animals are poor predictors of cancer risk to humans. Occup Environ Med. 2010;67(10):720.
- Manuppello J and Willett C. Longer rodent bioassay fails to address two-year bioassay’s flaws. Environ Health Persp. 2008;116(12):A516-A517.
- Currie A. Challenging the legal basis of the rodent carcinogenicity test in the United Kingdom [poster]. Linz, Austria: European Society for Alternatives to Animal Testing 12th annual congress; 2008.
- Wasted money, wasted lives: a layperson’s guide to the problems with rodent cancer studies and the National Toxicology Program. Published 2006.
- PETA International Science Consortium. Non-testing approaches: QSARs, grouping and read-across: a guide to sources of information and advice.
- Aladjov H, Clippinger AJ, Sullivan KM, Veith G. Effectopedia: an open collaborative platform for AOP development and application [poster]. San Diego, California: Society of Toxicology 54th annual meeting; 2015.
- Sullivan KM, Manuppello JR, Willett CE. Building on a solid foundation: SAR and QSAR as a fundamental strategy to reduce animal testing. SAR QSAR Environ Res. 2014;25(5):357-365.
- Manuppello J. Category approaches, read-across, (Q)SAR – European Centre for Ecotoxicology and Toxicology of Chemicals’ Technical Report 116. AltTox.org. 2013.
- Currie A. Implications of postponement of the 2013 deadline for implementation of the seventh amendment to the cosmetics directive [poster]. Linz, Austria: European Society for Alternatives to Animal testing 13th annual congress; 2010.
Dermal Sensitization Testing
- Clippinger AJ, Keller D, McKim JM Jr, Witters H, Van Rompay AR. Inter-laboratory validation of an in vitro method to classify skin sensitizers [poster]. Phoenix, Arizona: Society of Toxicology 53rd annual meeting; 2014.
Endocrine Disruptor Screening Program
- Bishop PL and Willett C. The use and acceptance of other scientifically relevant information (OSRI) in the U.S. Environmental Protection Agency (EPA) Endocrine Disruptor Screening Program. Birth Defects Res B Dev Reprod Toxicol. 2014; 101(1):3-22.
- Willett C, Bishop PL, Sullivan KM. Reducing EPA’s animal testing. AV Magazine. 2012; 1:22-23.
- Willett C, Bishop PL, Sullivan KM. Application of an integrated testing strategy to the U.S. EPA Endocrine Disruptor Screening Program. Toxicol Sci. 2011;123(1):15-25.
- Willett C, Bishop PL, Sullivan KM. A strategy for reducing animal use in the U.S. EPA’s Endocrine Disruption Screening Program [presentation]. Montréal, Québec, Canada: 8th World Congress on Alternatives and Animal Use in the Life Sciences; 2011.
- Brown J, Beck N, Manuppello J, Suiter S, Sullivan KM, Willett C. Toxicity testing in the 21st century and reforming the science of EPA’s Endocrine Disruptor Screening Program [poster]. Denver, Colorado: American Public Health Association 138th annual meeting; 2010.
- Willett C. Need for a mechanism-based approach to evaluating endocrine active substances [presentation]. Baltimore, Maryland: 21st Century Validation Strategies for 21st Century Tools; 2010.
- Willett C, Beck N, Brown J, Manuppello J, Suiter S, Sullivan KM. Fulfilling data requirements for the US EPA Endocrine Disruptor Screening Program using existing and nontraditional data [poster]. Linz, Austria: European Society for Alternatives to Animal Testing 13th annual congress; 2010.
- Willett C and Sullivan KM. Application of an intelligent testing strategy to the US EPA Endocrine Disruptor Screening Program [poster]. Baltimore, Maryland: Society of Toxicology 48th annual meeting; 2009.
- Stoddart G, Faβbender C, Bishop P, Halder M, Sullivan KM. Strategies to reduce the number of fish used in aquatic toxicity tests [poster]. Nantes, France: SETAC Europe 26th annual meeting; 2016.
- Dozier S. Modern analytical methods best ensure food safety: moving towards effective human-relevant food safety protocols [poster]. 2006.
High Production Volume Chemical Testing Program
- Bishop PL, Manuppello J, Willett C, Sandler J. Animal use and lessons learned in the US High Production Volume Chemicals Challenge Program. Environ Health Persp. 2012;120(12):1631-1639.
- Manuppello J, Willett C, Sandler J. US Environmental Protection Agency High Production Volume Chemicals Challenge Program: accounting for the animals [poster]. Rome, Italy: 7th World Congress on Alternatives and Animal Use in the Life Sciences; 2009.
- Sandusky CB, Even M, Stoick K, Sandler J. Strategies to reduce animal testing in US EPA’s HPV Programme. ALTEX. 2006;23:117-119.
- Nicholson A, Sandler J, Seidle T. An evaluation of the US High Production Volume (HPV) Chemical-Testing Programme: a study in (ir)relevance, redundancy and retro thinking. Altern Lab Anim. 2004;32 Suppl 1A:335-341.
Implementation of Alternative Methods
- Clippinger AJ, Hill E, Curren R, Bishop PL. Bridging the gap between regulatory acceptance and industry use of non-animal methods. 2016. doi: 10.14573/altex.1601311.
- Manuppello JR, Charles-Horvath P, Sandler J. Avoiding dermal systemic toxicity testing. Appl In Vitro Toxicol. 2015;1(3):173-174.
- Alternative methods endorsed by the European Centre for the Validation of Alternative Methods (ECVAM), the U.S. Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) and/or the Organisation for Economic Co-operation and Development (OECD). 2014.
- Brown J. Problems and progress with replacing the use of animals for skin corrosion testing. Alttox.org. 2013.
- Willett C and Sullivan KM. The impact of US adoption of the UN Globally Harmonized System on the use of in vitro methods for ocular and dermal irritation and corrosion [poster]. 2011.
- Baines J, Stoddart G. Rebuttal to the letter to the editor regarding: The sympathy of policy-makers towards animal-rights activists, and the future of biomedical research. Regul Toxicol Pharmacol. 2014;70(3):733-734.
- Sullivan KM, Beck N, Sandusky C, Willett C. A discussion of the impact of US chemical regulation legislation on the field of toxicity testing. Toxicol In Vitro. 2011;25(6):1231-1236.
- Sullivan KM, Beck N, Willett C, Sandusky C. A qualitative and quantitative examination of the impact of chemical regulation legislation on the field of toxicity testing. 2010;27, Suppl. 2/10.
- Sullivan KM, Beck N, Sandusky C, Willett C. New chemical regulation policies as a means to revolutionize toxicity testing [presentation]. Rome, Italy: 7th World Congress on Alternatives and Animal Use in the Life Sciences; 2009.
- Sharma M, Rothen-Rutishauser B, Barosova H, Chortarea S., Zerimariam F., Clift MJD, Stone V, Hayden P, Maione A, Clippinger AJ. Development of an in vitro test to assess the inhalation toxicity of nanomaterials [poster]. Boston, Massachusetts: 8th International Nanotoxicology Congress; 2016.
- Sharma M, Nikota J, Halappanavar S, Castranova V, Rothen-Rutishauser B, Clippinger AJ. Predicting pulmonary fibrosis in humans after exposure to multi-walled carbon nanotubes (MWCNTs). Arch Toxicol. 2016;90(7):1605-1622.
- Clippinger AJ, Ahluwalia A, Allen D, Bonner JC, Casey W, Castranova V, David RM, Halappanavar S, Hotchkiss JA, Jarabek AM, Maier M, Polk W, Rothen-Rutishauser B, Sayes CM, Sayre P, Sharma M, Stone V. Expert consensus on an in vitro approach to assess pulmonary fibrogenic potential of aerosolized nanomaterials. Arch Toxicol. 2016;90(7):1769-1783.
- Polk W, Sharma M, Sayes CM, Hotchkiss JA, Clippinger AJ. Aerosol generation and characterization of multi-walled carbon nanotubes exposed to cells cultured at the air-liquid interface. Part Fibre Toxicol. 2016;13(1):20.
- Sharma M. ‘Nano’ Today. Alttox.org. 2016.
- Sharma M, Rothen-Rutishauser B, Barosova H, Chortarea S, Zerimariam F, Clift MJD, Stone V, Hayden P, Maione A, Clippinger AJ. Development of an in vitro test to assess the inhalation toxicity of nanomaterials [poster]. New Orleans, Louisiana: Society of Toxicology 55th annual meeting; 2016.
- Sharma M, Shatkin J, Cairns C, Canady R, Clippinger AJ. Framework to evaluate exposure relevance and data needs for risk assessment of nanomaterials using in vitro testing strategies. Risk Analysis. 2016. doi: 10.1111/risa.12581.
- Godwin H, Nameth C, Avery D, Bergeson L, Bernard D, Beryt E, Boyes W, Brown S, Clippinger AJ, Cohen Y, Doa M, Olgilvie Hendren C, Holden P, Houck K, Kane A, Klaessig F, Kodas T, Landsiedel R, Lynch I, Malloy T, Miller M, Muller J, Oberdorster G, Pleus R, Sayre P, Stone V, Sullivan K, Tentschert J, Wallis P, and Nel AE. Nanomaterial categorization for assessing risk potential to facilitate regulatory decision-making. ACS Nano. 2015;9(4):3409-3417.
- Sharma M, Shatkin JA, Cairns C, Canady R, Clippinger AJ. Framework to evaluate exposure relevance and data needs for risk assessment of nanomaterials using in vitro testing strategies [poster]. San Diego, California: Society of Toxicology 54th annual meeting; 2015.
- Sharma M, Stoddart G, Clippinger AJ. A tiered-testing strategy for nanomaterial hazard assessment [poster]. Egmond aan Zee, Netherlands: European Society of Toxicology In Vitro International Conference; 2014.
- Goodman J, Chandna A, Roe K. Trends in animal use at US research facilities. J Med Ethics. doi:10.1136/medethics-2014-102404.
- Goodman JR, Chandna A, Borch C. Does accreditation by the Association for Assessment and Accreditation of Laboratory Animal Care International (AAALAC) ensure greater compliance with animal welfare laws? J Appl Anim Welf Sci. 2015;18(1):82-91.
- Hansen LA, Goodman JR, Chandna A. Analysis of animal research ethics committee membership at American institutions. 2012;2(1):68-75.
PETA International Science Consortium Information
- Stoddart G, Brown J. A campaign to end animal testing: introducing the PETA International Science Consortium Ltd. Altern Lab Anim. 2014;42(6):387-393.
- PETA International Science Consortium Ltd. [brochure].
- PETA International Science Consortium Ltd. (German language version) [brochure].
- Stoddart G. Minimising animal tests through education and training [presentation]. London, UK: Lush Prize Conference; 2015.
Public Opinion on Animal Testing
- Goodman JR, Borch CA, Cherry E. Mounting opposition to vivisection. 2012;11(2):68-69.
Registration, Evaluation, Authorization and Restriction of Chemicals (REACH)
- Faβbender C, Stoddart G, Baines J, Clippinger AJ. Non-animal testing: it’s within REACH (References) [poster] Nantes, France: SETAC Europe; 2016.
- Brown J, Barroso J, Patlewicz G, Butterworth R, Clippinger AJ, Stoddart G. Effectiveness of toxicology-based webinars to promote nonstandard methods for REACH [poster]. San Diego, California: Society of Toxicology 54th annual meeting; 2015.
- Patlewicz G, Cronin M, Baines J. How QSARs and read-across can help address REACH 2018. com. 2015.
- Stoddart G and Sullivan KM. Strategies to reduce the number of fish used in ecotoxicity tests [poster]. Prague, Czech Republic: 9th World Congress on Alternatives and Animal Use in the Life Sciences; 2014.
- Baines J, Stoddart G. Avoidable animal tests continue under REACH. com. 2014.
- QSARs and REACH: A guide to sources of information and advice. 2012.
- Rizzuto P and Willett C. REACH and the future of toxics legislation [presentation]. Washington, DC: SLA 2009 Annual Conference and INFO-EXPO; 2009.
Teaching and Medical Training
- Roe KV, Lopresti-Goodman SM, Goodman JR. Alternatives to animal use in undergraduate psychology education [poster]. 2015.
- Gala SG, Goodman JR, Murphy MP, Balsam MJ. Use of animals by NATO countries in military medical training exercises: an international survey. Mil Med. 2012;177(8):907-910.
- Valliyate M, Robinson NG, Goodman JR. Current concepts in simulation and other alternatives for veterinary education: a review. Veterinarni Medicina. 2012;57(7):325-337.
- Behrsing H, Raabe H, Manuppello J, Bombick B, Curren R, Sullivan K, Sethi S, Phipps R, Tesfaigzi Y, Yan S, D’Ruiz C, Tarran R, Constant S, Phillips G, Gaça M, Hayden P, Cao X, Mathis C, Hoeng J, Braun A, Hill E. Assessment of in vitro COPD models for tobacco regulatory science: Workshop proceedings, conclusions and paths forward for in vitro model use. Altern Lab Anim. 2016;44(2):129-166.
- Manuppello JR, Sullivan KM. Toxicity assessment of tobacco products in vitro. Altern Lab Anim. 2015;43(1):39-67.
- Dozier S, Brown J, Currie A. Bridging the gap between validation and implementation of non-animal veterinary vaccine potency testing methods. 2011;1:414-432.
- Dozier S, Brown J, Currie A. Bridging the gap between validation and implementation of non-animal potency testing methods [poster]. Bethesda, Maryland: Interagency Coordinating Committee on the Validation of Alternative Methods International Workshop on Alternative Methods to Reduce, Refine, and Replace the Use of Animals in Vaccine Potency and Safety Testing: State of the Science and Future Directions; 2010.
To request hard copies of the above documents, please e-mail [email protected].