In 2015, the PETA International Science Consortium Ltd. (PISC) and MatTek Corporation teamed up to offer free 3D reconstructed human tissue models.
MatTek’s human cell-based tissues—including dermal, ocular, respiratory, intestinal, oral, and vaginal models—are used for regulatory safety testing, product development, and basic research applications. To meet regulatory testing requirements, the Epiderm™ and EpiOcular™ models can be used according to internationally accepted test guidelines to determine chemical safety throughout the cosmetic, chemical, pharmaceutical, and household product industries. In product development and basic research, 3D models have been used in a broad range of experimental applications including drug delivery, inflammation, metabolism, apoptosis, and gene analysis, amongst many others.
Free or discounted MatTek tissues were awarded to select researchers who submitted a brief (500 words or less) proposal on how MatTek tissues could be used in their work to reduce animal testing.
45 proposals from more than a dozen countries were submitted, demonstrating the breadth of applications in which MatTek tissues can replace the use of animals and a clear interest within the scientific community to use nonanimal methods to predict human health outcomes. Originally, three winners were to be selected; however, because there were so many excellent proposals, four winners were selected and an additional four were chosen to receive discounted tissues.
The winners, who will receive $5,000 worth of MatTek tissue, are:
- Kathryn Page, PhD, The Clorox Company, for testing eye and skin irritancy potential of product formulations with EpiOcularTM and EpiDermTM;
- Susan C. Tilton, PhD, Oregon State University, for computationally modeling the carcinogenic risk of polycyclic aromatic hydrocarbon mixtures with EpiAirwayTM;
- Jan Willem de Vries, PhD, University Eye Hospital Tübingen, for testing an ophthalmic drug carrier system based on DNA nanoparticles with EpiOcularTM; and
- Hyun Jung Kim, PhD, University of Texas at Austin, for modeling human intestinal inflammatory disease with EpiIntestinalTM.
Those who received an Honorable Mention and will receive a fifty percent discount on MatTek tissues are:
- Susanne Kolle, PhD, BASF SE, for testing eye irritancy potential of agrochemical formulations with EpiOcularTM;
- Ian Jarvis, PhD and Volker Arlt, PhD, King’s College of London, for studying air pollution by testing aerosolized particulate matter with EpiAirwayTM;
- Daniel Packert, PhD, Barry University, to develop a method using EpiDermTM to study treatment options for wounds infected with multiple microorganisms;
- Joseph Skeate, PhD, University of Southern California, to develop a regulatory test method to evaluate potential anti-inflammatory responses of essential oils using EpiDermTM.